Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells

2021-04-03

Special Notice to Applicants The State of Illinois is currently testing an online application system. Applications for the positions listed below can only be submitted online. The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils. IL-4 is a multifunctional cytokine with B-cell stimulatory and Th2-promoting properties. IL-4 can rescue B-cells from apoptosis, enhancing their survival, 60 and is responsible for immunoglobulin isotype switching to IgG1 and IgE. 61 A T-cell suppressor role for this cytokine has also been suggested.

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SPRINGFIELD – The Illinois Department of Public Health (IDPH) today announced Region 4 (Bond, Clinton, Madison, Monroe, Randolph, St. Clair, Washington) is moving to Phase 4 of the Restore Illinois Plan effective today.

Because both IL-4 and IL-13 use the IL-4Ralpha as a receptor component, these cytokines activate many common signaling pathways. Both of these cytokines use Janus kinases (JAKs) to initiate signaling and activate signal transducer and activator of transcription-6 (STAT6), which is a transcription factor required for many of their biologic functions.

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IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1.Among its related pathways are Interleukin-4 and 13 signaling and Innate Immune System.Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and interleukin-4 receptor

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IL-4 and IL-13 including CD4+ T-cells and cells of the innate immune system, the structure of their receptors, their binding potency and kineti cs, and their signal tran sduction. Furthermore, we present evidence for the differential effects of IL-4 and IL-13 acting via these receptor complexes on features of allergic lung inflam mation.

IL-4 signaling is required for the differentiation of Th2 and Th9 cells and regulates immunoglobulin class switching in B cells. In addition, IL-4 plays a central role in the development of allergic inflammation and asthma by enhancing the expression of Fc epsilon RI on B cells, mast cells, and basophils, promoting mast cell survival and proliferation, and inducing mast cell, basophil, and Complete information for IL4R gene (Protein Coding), Interleukin 4 Receptor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells.

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